Controlling Pain Eliot S. Krames, MD, FACPM, Ernest H. Rosenbaum, MD, and Malin Dollinger, MD "Pain is an even more terrible lord of mankind than even death itself." — Albert Schweitzer Fear of pain is a large part of any patient's fear of cancer. Sixty to 90 percent of people with advanced cancer develop pain severe enough that they need some type of pain-relieving therapy, so this is a realistic concern. But not all cancers produce pain equally, and some cancers, even when advanced, may not cause pain at all. Cancers involving bone, either directly or through spread, or the abdomen are usually associated with pain when advanced. Cancers of the blood system such as leukemias or lymphomas may not be.